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KMID : 0368019950180010401
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Journal of Soonchunhyang University
1995 Volume.18 No. 1 p.401 ~ p.414
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An Immunohistochemical Study for Distribution of P-glycoprotein in Gastric Adenocarcinoma
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Abstract
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P-glycoprotein, as a pleotropic membrane transport protein, shows specific localization in many normal tissue and malignant tumor, It act as an energy dependent drug pump in malignant tumors and makes difficulty for treating these tumors with
anticancer
drugs many malignant tumors such as colon carcinoma, renal cell carcinoma, hepatoma, islet cell tumor of pancreas, and adrenal cortical carcinoma, show high expression of P-glycoprotein and resistance to chemotherapy. However reports for
P-glycoprotein
in gastric adenocarcinoma is rare. The difference of its expression according to differentiation of gastric adenocarcinoma has been studied and its results are controversial. To observe the relationship of P-glycoprotein positivity acording to
differentiation of carcinoma, age and sex, adenocarcinoma 82 cases and dysplastic lesions 12 cases were analysed then processed for immunohistochemical stain by avidin-biotin complex using mAB JSB-1.
@ES The results were as followings:
@EN 1. Positive rate of P-glycoprotein in gastric adenocarcinoma and dysplastic lesions were 48.78%(40/82) and 50%(6/12).
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KEYWORD
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